A major new clinical trial published in The Journal of Nutrition (May 2025) has reinforced the benefits of Affron®, Pharmactive’s standardized saffron extract, in promoting emotional wellbeing among adults with symptoms of low mood. With more than 200 participants, this is the most extensive study on Affron® to date.
The 12-week investigation focused on adults experiencing signs of mild depression—a common but often overlooked condition affecting quality of life. Participants received either 28 mg/day of Affron® or a placebo. Mood, stress, anxiety, and sleep quality were evaluated using validated scales.
Key outcomes
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72% of those taking Affron® showed significant improvements in emotional wellbeing vs. 54% in the placebo group.
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Symptom scores dropped by an average of 53% on the DASS-21 scale.
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Benefits began to appear as early as week five.
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Participants with baseline sleep issues also reported better sleep quality.
“This is our most comprehensive trial so far,” notes Dr. Inés Morán, Scientific Studies Manager at Pharmactive. “With its larger sample size and longer duration, it confirms both the efficacy and safety of Affron® under real-world conditions.”
A distinctive saffron extract
Affron® is derived from Crocus sativus L. and standardized to ≥3.5% Lepticrosalides®, its main active compounds. Produced using Pharmactive’s proprietary clean extraction technology, it preserves the full bioactive profile without the use of organic solvents.
Key differentiators of Affron® include:
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Rapid onset of action, with measurable effects within the first hour.
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Low effective daily dose: 28 mg per day (or 14 mg before bedtime for sleep support).
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Demonstrated safety across diverse populations, including adolescents and menopausal women.
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Backed by 11 published clinical trials
Bridging tradition and innovation
Saffron has a long history in traditional wellness practices. With Affron®, modern science has unveiled its mechanisms of action, including neurotransmitter modulation, antioxidant and anti-inflammatory effects, and regulation of the HPA axis.
Affron® represents a unique blend of heritage and evidence-based innovation—offering a safe, natural, and clinically validated solution for enhancing emotional balance.
